Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent …

AJ Hannan - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Environmental enrichment (EE) increases levels of novelty and complexity, inducing
enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE has been found …

The interaction between autophagy and neuroinflammation in major depressive disorder: from pathophysiology to therapeutic implications

M Tang, T Liu, P Jiang, R Dang - Pharmacological research, 2021 - Elsevier
The past decade has revealed neuroinflammation as an important mechanism of major
depressive disorder (MDD). Nod-like receptors family pyrin domain containing 3 (NLRP3) …

Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in 5xFAD mouse model

C Griñán-Ferré, V Izquierdo, E Otero… - Frontiers in Cellular …, 2018 - frontiersin.org
Cumulative evidence shows that modifications in lifestyle factors constitute an effective
strategy to modulate molecular events related to neurodegenerative diseases, confirming …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Aggression in group-housed male mice: a systematic review

EM Weber, J Zidar, B Ewaldsson, K Askevik, E Udén… - Animals, 2022 - mdpi.com
Simple Summary When male mice are kept in groups at animal facilities, aggressive
interactions between cage mates are not uncommon. Systematically reviewing previous …

Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits

E Beurel, RS Jope - Translational psychiatry, 2014 - nature.com
Suicide is one of the leading causes of death in the United States, yet it remains difficult to
understand the mechanistic provocations and to intervene therapeutically. Stress is …

Environmental enrichment as an experience-dependent modulator of social plasticity and cognition

C Gubert, AJ Hannan - Brain Research, 2019 - Elsevier
Social plasticity is the ability to adaptively change the expression of social behaviour
according to experience, allowing animals to optimize their social relationships in the …

The effects of environmental enrichment on depressive and anxiety-relevant behaviors in socially isolated prairie voles

AJ Grippo, E Ihm, J Wardwell, N McNeal… - Psychosomatic …, 2014 - journals.lww.com
Objectives Social isolation is associated with depression, anxiety, and negative health
outcomes. Environmental enrichment, including environmental and cognitive stimulation …

Effects of repeated social defeat on adolescent mice on cocaine‐induced CPP and self‐administration in adulthood: integrity of the blood–brain barrier

M Rodríguez‐Arias, S Montagud‐Romero… - Addiction …, 2017 - Wiley Online Library
Social stress in adulthood enhances cocaine self‐administration, an effect that has been
related with an increase in extracellular signal‐regulated kinase and p38α mitogen …