Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

The search for efficient and selective methods for the divergent synthesis of multi‐substituted
aminotetralins is of much interest and importance. We report herein for the first time the …

The design of efficient ligands remains a key challenge in drug discovery. In the quest for
lead-like ligands for the FK506-binding protein 51 (FKBP51), we designed two new classes …

Publisher Summary The understanding of the thermodynamics of the events that are
governing molecular recognition is essential for the practice of medicinal chemistry. This …

Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB 1, BB 2, BB 3 (nomenclature
recommended by the NC-IUPHAR Subcommittee on bombesin receptors,[109]). BB 1 and …

Replacement of the core β-amino acid in our previously reported piperidine acetic acid and
β-phenylalanine-based Bradykinin B1 antagonists by dihydroquinoxalinone acetic acid …

The Kinin Family. Kinins are naturally occurring vasoactive peptide hormones, which are
known to be important mediators of a variety of biological effects, including cardiovascular …

The bradykinin B1 receptor is rapidly induced upon tissue injury and inflammation,
stimulating the production of inflammatory mediators resulting in plasma extravasation …

Background: For> 20 years, pharmaceutical companies and academic centers have been
developing bradykinin antagonists. The patent literature on these molecules (up to and …