The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …

A systems pharmacology model typically integrates pharmacokinetic, biochemical network,
and systems biology concepts into a unifying approach. It typically consists of a large …

Despite advances in biomedical research that have deepened our understanding of cancer
hallmarks, resulting in the discovery and development of targeted therapies, the success …

Quantitative systems pharmacology (QSP) approaches have been increasingly applied in
the pharmaceutical since the landmark white paper published in 2011 by a National …

This article gives an overview of a technique called optimal control, which is used to
optimize real-world quantities represented by mathematical models. I include background …

Abstract Systems pharmacology approaches have the capability of quantitatively linking the
key biological molecules relevant to a drug candidate's mechanism of action (drug-induced …

Quantitative systems pharmacology (QSP) modeling has become increasingly important in
pharmaceutical research and development, and is a powerful tool to gain mechanistic …

Optimizing anticancer therapeutics needs to account for variable drug responses in
heterogeneous cell populations within the tumor as well as in organs of toxicity. To address …

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis.
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …

Following the first CNS Anticancer Drug Discovery and Development Conference, the
speakers from the first 4 sessions and organizers of the conference created this White Paper …