The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …

Background Neurodegenerative diseases are among the most common diseases in older
adults worldwide. Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the …

Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Stilbenes are phytoalexins, and their biosynthesis can occur through a natural route
(shikimate precursor) or an alternative route (in microorganism cultures). The latter is a …

Current studies have found that butyrylcholinesterase (BuChE) replaces the biological
function of acetylcholinesterase (AChE) in the late stage of Alzheimer's disease. Species in …

Neurodegenerative diseases (NDDs) are on the rise in the world. Therefore, it is a critical
issue to reveal the precise pathophysiological mechanisms and novel therapeutic strategies …

We aimed to investigate whether polydatin could suppress stress-induced depression-and
anxiety-like behaviors in a mouse model. Mice were divided into the control group, chronic …

A wide range of life-threatening conditions with complicated pathogenesis involves
neurovascular disorders encompassing Neurovascular unit (NVU) damage. The …

Methotrexate (MTX) is used to treat rheumatoid arthritis, acute leukemia, and psoriasis. MTX
can cause certain side effects, such as myelosuppression, while the exact mechanism of …