Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …

This review is a survey of various approaches to targeting cytotoxic anticancer drugs to
tumors primarily through biomolecules expressed by cancer cells or associated vasculature …

Background Despite aggressive standard of care (SOC) treatment, survival of malignant
gliomas remains very poor. This Phase II, prospective, matched controlled, multicenter trial …

Gene therapy of cancer is a novel approach with the potential to selectively eradicate tumour
cells, whilst sparing normal tissue from damage. In particular, gene‐directed enzyme …

The long-term consequences of adenovirus-mediated conditional cytotoxic gene therapy for
gliomas remain uncharacterized. We report here detection of active brain inflammation 3 …

Direct transfer of prodrug activation systems into tumors was demonstrated to be an
attractive method for the selective in vivo elimination of tumor cells. However, most current …

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

Despite extensive surgery for glioblastoma, residual tumor cells always lead to relapse.
Gene therapy based on retrovirus-mediated gene transfer of herpes simplex virus type 1 …

Prostaglandin E2 (PGE2), a major COX metabolite, plays important roles in several facets of
tumor biology. We characterized the contribution of the PGE2 EP2 receptor to cancer …

Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These
tumors are highly invasive, very aggressive, and often infiltrate critical neurological areas …