Abstract Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating
proteostasis, long recognized for its function in protein folding and maturation. A view is …

Our review seeks to elucidate the current state-of-the-art in studies of 70-kilodalton-weighed
heat shock proteins (Hsp70) in neurodegenerative diseases (NDs). The family has already …

A repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate …

Many RNA-binding proteins (RBPs), particularly those associated with RNA granules,
promote pathological protein aggregation in neurodegenerative diseases. Here, we …

Hsp90s are ATP-dependent chaperones that collaborate with co-chaperones and Hsp70s to
remodel client proteins. Grp94 is the ER Hsp90 homolog essential for folding multiple …

The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …

This article highlights the potential contribution of biological codes to the course and
dynamics of evolution. The concept of organic codes, developed by Marcello Barbieri, has …

Oculopharyngeal muscular dystrophy (OPMD) is a rare muscle disease characterized by an
onset of weakness in the pharyngeal and eyelid muscles. The disease is caused by the …

Phytochrome B (phyB) is a red and far‐red photoreceptor that promotes light responses.
Upon photoactivation, phyB enters the nucleus and forms a molecular condensate called a …

Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial molecular
chaperone modulating cellular metabolism and signaling pathways by altering the …