Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
[HTML][HTML] Targeting macrophages in cancer immunotherapy
Z Duan, Y Luo - Signal transduction and targeted therapy, 2021 - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …
Macrophage functional diversity in NAFLD—more than inflammation
Macrophages have diverse phenotypes and functions due to differences in their origin,
location and pathophysiological context. Although their main role in the liver has been …
location and pathophysiological context. Although their main role in the liver has been …
The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …
of the most global problematic metabolic diseases with rapidly increasing prevalence and …
[HTML][HTML] Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH
S Daemen, A Gainullina, G Kalugotla, L He, MM Chan… - Cell reports, 2021 - cell.com
Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …
steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding …
Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
K Kazankov, SMD Jørgensen, KL Thomsen… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …
Chronic tissue inflammation and metabolic disease
YS Lee, J Olefsky - Genes & development, 2021 - genesdev.cshlp.org
Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …
[PDF][PDF] Pathogenesis of nonalcoholic steatohepatitis: an overview
G Parthasarathy, X Revelo… - Hepatology …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases
characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected …
characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected …
The ménage à trois of autophagy, lipid droplets and liver disease
Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …
building blocks that are indispensable for liver functions. Energy deficiencies are …