Objectives: Use systematic review and meta-analytic methodology to estimate the pooled
incidence, prevalence, and proportion of delirium cases for each delirium subtype …

Objective: To revise the “Clinical Practice Guidelines for the Sustained Use of Sedatives and
Analgesics in the Critically Ill Adult” published in Critical Care Medicine in 2002. Methods …

Context Long-term sedation with midazolam or propofol in intensive care units (ICUs) has
serious adverse effects. Dexmedetomidine, an α 2-agonist available for ICU sedation, may …

Background The influence of dexmedetomidine on postoperative delirium (POD) in adult
surgical patients remains controversial. We aimed to analyse whether dexmedetomidine use …

Delirium is characterized by a disturbance of consciousness with accompanying change in
cognition. Delirium typically manifests as a constellation of symptoms with an acute onset …

Increasing lines of evidence identified that dexmedetomidine (DEX) exerted protective
effects against sepsis-stimulated acute lung injury via anti-inflammation, anti-oxidation and …

Outcomes of critically ill patients can be improved by applying evidence-based therapies for
the 'liberation'from mechanical ventilation and sedation, and the 'animation'through early …

Dexmedetomidine is a potent alpha-2-adrenergic agonist, more selective than clonidine,
with widespread actions on the mammalian brain that include sedation, anaesthetic-sparing …

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

Introduction Small-study effects refer to the fact that trials with limited sample sizes are more
likely to report larger beneficial effects than large trials. However, this has never been …