Due to the fact that mRNA technology allows the production of diverse vaccines and
treatments in a shorter time frame and with reduced expense compared to conventional …

Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …

The remarkable capacity of immunotherapies to induce durable regression in some patients
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …

A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …

The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a
central focus for engaging the immune system in the fight against cancer. Basic science …

The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …

A review of cancer immunotherapy: from the past, to the present, to the future Page 1 S87
Current Oncology, Vol. 27, Supp. 2, April 2020 © 2020 Multimed Inc. REVIEW ARTICLE A …

Messenger ribonucleic acid (mRNA)-based drugs, notably mRNA vaccines, have been
widely proven as a promising treatment strategy in immune therapeutics. The extraordinary …

Certain bacterial colonists induce a highly specific T cell response. A hallmark of this
encounter is that adaptive immunity develops preemptively, in the absence of an infection …