Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …

The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity …

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …

Accumulating evidence points to Akkermansia muciniphila as a novel candidate to prevent
or treat obesity-related metabolic disorders. We recently observed, in mice and in humans …

In order to assess potential associations between autism spectrum disorder (ASD)
phenotype, functional GI disorders and fecal microbiota, we recruited simplex families, which …

Intestinal surface changes in size and function, but what propels these alterations and what
are their metabolic consequences is unknown. Here we report that the food amount is a …

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids for energy
metabolism, membrane synthesis and production of lipid-derived signaling molecules. While …

Objective Observations of microbial dysbiosis in patients with rheumatoid arthritis (RA) have
raised interest in studying microbial–mucosal interactions as a potential trigger of RA. Using …

The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …