Synthesis and characterization of Co (II), Ni (II), Cu (II) and Zn (II) chelates: DFT calculations, molecular docking and biological applications
An azo dye ligand,(Z)-2-(benzo [d] thiazol-2-yl)-2-(2-p-tolylhydrazono) acetonitrile (HL) and
its Co (II)(1), Cu (II)(2), Ni (II)(3) and Zn (II)(4) chelates were synthesized and considered …
its Co (II)(1), Cu (II)(2), Ni (II)(3) and Zn (II)(4) chelates were synthesized and considered …
Unveiling the Therapeutic Potential of Quinazolinone Derivatives in Cancer Treatment: A Comprehensive Exploration
J Kaur, S Kaur, Muskan, N Kaur, V Kumar… - …, 2024 - Wiley Online Library
Quinazolinone derivatives have garnered attention for their diverse biological activities,
including anticancer properties. This review combines findings from 2018 to 2024, focusing …
including anticancer properties. This review combines findings from 2018 to 2024, focusing …
Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: Design, synthesis, anti-proliferative …
Nanotechnology-based strategies can overcome the limitations of conventional cancer
therapies. Hence, novel series of pyrimidine Schiff bases (4–9) were employed in the …
therapies. Hence, novel series of pyrimidine Schiff bases (4–9) were employed in the …
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Cancer stands as one of the deadliest diseases, ranking second in terms of its global impact.
Despite the presence of numerous compelling theories concerning its origins, none have …
Despite the presence of numerous compelling theories concerning its origins, none have …
Novel Aminopyrimidine-2, 4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and …
S El-Kalyoubi, SA El-Sebaey, SM Elfeky… - Pharmaceuticals, 2023 - mdpi.com
Structural-based drug design and solvent-free synthesis were combined to obtain three
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …
Synthesis and In Vitro Study of pyrimidine–phthalimide Hybrids As VEGFR2 Inhibitors With Antiproliferative Activity
Aim: Thalidomide, a once notorious sedative, is now clinically used as an antitumor agent.
We aimed to use it as a lead compound for designing pyrimidine–phthalimide hybrids …
We aimed to use it as a lead compound for designing pyrimidine–phthalimide hybrids …
Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3H)-Ones Bearing Urea Functionality as Potential VEGFR-2 Inhibitors
MM Al-Sanea, HM Hafez, AAB Mohamed… - Drug Design …, 2024 - Taylor & Francis
Background In response to the urgent need for continuous discovery of new anti-proliferative
agents, a new series of quinazoline compounds 5a-r was prepared. Methods As a reference …
agents, a new series of quinazoline compounds 5a-r was prepared. Methods As a reference …
GC-MS profiling and evaluation of acute oral toxicity, anti-tumour, antimicrobial and antioxidant activities of Croton socotranus Balf. f. aerial parts: in-vitro, in-vivo and in …
IA Al-Hakami, A El-Shaibany… - Natural Product …, 2023 - Taylor & Francis
Croton socotranus Balf. f. shrub is widely used traditionally in Asia as an anti-infective. The
study was conducted for metabolite profiling, oral acute toxicity and antioxidant studies …
study was conducted for metabolite profiling, oral acute toxicity and antioxidant studies …