The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …
craving are often provoked by acute exposure to the self-administered drug or related drugs …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
Losing control: excessive alcohol seeking after selective inactivation of cue-responsive neurons in the infralimbic cortex
S Pfarr, MW Meinhardt, ML Klee… - Journal of …, 2015 - Soc Neuroscience
Loss of control over drinking is a key deficit in alcoholism causally associated with
malfunction of the medial prefrontal cortex (mPFC), but underlying molecular and cellular …
malfunction of the medial prefrontal cortex (mPFC), but underlying molecular and cellular …
The intersection of stress and reward: BNST modulation of aversive and appetitive states
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …
Role of cues and contexts on drug‐seeking behaviour
Environmental stimuli are powerful mediators of craving and relapse in substance‐abuse
disorders. This review examined how animal models have been used to investigate the …
disorders. This review examined how animal models have been used to investigate the …
Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking
A central problem in the treatment of drug addiction is high rates of relapse to drug use after
periods of forced or self-imposed abstinence. This relapse is often provoked by exposure to …
periods of forced or self-imposed abstinence. This relapse is often provoked by exposure to …
Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry
SD Clark, DM Duangdao, S Schulz… - Journal of …, 2011 - Wiley Online Library
Neuropeptide S (NPS) is the endogenous ligand for GPR154, now referred to as
neuropeptide S receptor (NPSR). Physiologically, NPS has been characterized as a …
neuropeptide S receptor (NPSR). Physiologically, NPS has been characterized as a …
Stress-related neuropeptides and addictive behaviors: beyond the usual suspects
Addictive disorders are chronic, relapsing conditions that cause extensive disease burden.
Genetic factors partly account for susceptibility to addiction, but environmental factors such …
Genetic factors partly account for susceptibility to addiction, but environmental factors such …
Modeling relapse in animals
R Martin-Fardon, F Weiss - Behavioral neurobiology of alcohol addiction, 2013 - Springer
Alcohol addiction is a chronically relapsing disorder characterized by compulsive alcohol
seeking and use. Alcohol craving and long-lasting vulnerability to relapse present a great …
seeking and use. Alcohol craving and long-lasting vulnerability to relapse present a great …
A cluster of neuropeptide S neurons regulates breathing and arousal
Neuropeptide S (NPS) is a highly conserved peptide found in all tetrapods that functions in
the brain to promote heightened arousal; however, the subpopulations mediating these …
the brain to promote heightened arousal; however, the subpopulations mediating these …