Mechanical regulation of early vertebrate embryogenesis
Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …
mechanical forces that shape the development of the entire embryo. Despite their …
Generation of extracellular morphogen gradients: the case for diffusion
KS Stapornwongkul, JP Vincent - Nature Reviews Genetics, 2021 - nature.com
Cells within developing tissues rely on morphogens to assess positional information.
Passive diffusion is the most parsimonious transport model for long-range morphogen …
Passive diffusion is the most parsimonious transport model for long-range morphogen …
Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart
MH Dominguez, AL Krup, JM Muncie, BG Bruneau - Cell, 2023 - cell.com
Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …
computational tools, we longitudinally reconstruct early murine cardiac development at …
Global Literature Analysis of Organoid and Organ‐on‐Chip Research
J Shoji, RP Davis, CL Mummery… - Advanced healthcare …, 2023 - Wiley Online Library
Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …
physiological, or pathological states of tissues and organs. These technologies are widely …
MOrgAna: accessible quantitative analysis of organoids with machine learning
N Gritti, JL Lim, K Anlaş, M Pandya… - …, 2021 - journals.biologists.com
Recent years have seen a dramatic increase in the application of organoids to
developmental biology, biomedical and translational studies. Organoids are large structures …
developmental biology, biomedical and translational studies. Organoids are large structures …
Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure
DL Shi - Cellular and Molecular Life Sciences, 2022 - Springer
Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …
shaping the basic embryonic body plan. Importantly, they operate through common cellular …
Stem-cell-based human and mouse embryo models
M Bao, J Cornwall-Scoones… - Current opinion in genetics …, 2022 - Elsevier
Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …
insight into early stages of mammalian development. Recent advances in synthetic …
A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly
A Sousa-Ortega, J Vázquez-Marín… - Nature …, 2023 - nature.com
The assembly of the embryo's primary axis is a fundamental landmark for the establishment
of the vertebrate body plan. Although the morphogenetic movements directing cell …
of the vertebrate body plan. Although the morphogenetic movements directing cell …
Establishment of the vertebrate body plan: Rethinking gastrulation through stem cell models of early embryogenesis
B Steventon, L Busby, AM Arias - Developmental Cell, 2021 - cell.com
A striking property of vertebrate embryos is the emergence of a conserved body plan across
a wide range of organisms through the process of gastrulation. As the body plan unfolds …
a wide range of organisms through the process of gastrulation. As the body plan unfolds …
In vitro endoderm emergence and self-organisation in the absence of extraembryonic tissues and embryonic architecture
S Vianello, M Lutolf - BioRxiv, 2020 - biorxiv.org
The endoderm is the cell lineage which gives rise in the embryo to the organs of the
respiratory and gastrointestinal system. In the mouse this may be the germ layer with the …
respiratory and gastrointestinal system. In the mouse this may be the germ layer with the …