Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Human genetics and preclinical studies have identified key contributions of TREM2 to
several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically …

Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer's
disease pathophysiology is somewhat ambiguous, with various phenotypes reported to be …

Polypyrimidine tract-binding protein 1 (PTBP1) regulates numerous alternative splicing
events during tumor progression and neurogenesis. Previously, PTBP1 downregulation was …

TMEM106B, a gene encoding a lysosome membrane protein, is tightly associated with brain
aging, hypomyelinating leukodystrophy, and multiple neurodegenerative diseases …

Tauopathies are a collection of neurodegenerative diseases characterized by the
accumulation of pathogenic aggregates of the microtubule‐associated protein tau. Despite …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …