Innate immune responses are tightly regulated by various pathways to control infections and
maintain homeostasis. One of these pathways, the inflammasome pathway, activates a …

The bladder supports a diversity of macrophage populations with functional roles related to
homeostasis and host defense, including clearance of cell debris from tissue, immune …

The NLRP3 inflammasome and IL-1β have recently been linked to the severity of
uropathogenic Escherichia coli (UPEC)-mediated urinary tract infection (UTI). However, not …

Abstract The host Toll-like Receptor-2 (TLR2) and Toll-like Receptor-4 (TLR4) play critical
roles in defense against Escherichia coli (E. coli) infection is well-known. The NLR pyrin …

Bacteria that occupy an intracellular niche can evade extracellular host immune responses
and antimicrobial molecules. In addition to classic intracellular pathogens, other bacteria …

Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infections. Nearly
half of all UPEC strains secrete hemolysin, a cytotoxic pore-forming toxin. Here, we show …

Pseudomonas aeruginosa is a common respiratory pathogen in cystic fibrosis (CF) patients
which undergoes adaptations during chronic infection towards reduced virulence, which can …

Urinary tract infections (UTI) frequently progress to chronicity in infected individuals but the
mechanisms of pathogenesis underlying chronic UTI are not well understood. We examined …

The spread and transfer of resistant pathogens is on the increase worldwide and it is
presently a cause of concern for health facilities, health organizations and governments …

Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to
the RNase A superfamily have a critical role in defending the bladder and kidney from …