Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

Covering: up to September 2009 This review covers the recent literature on the release
mechanisms for polyketides and nonribosomal peptides produced by microorganisms. The …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

Covering: 1999 to 2014 Type 1, α/β hydrolase-like thioesterase (TE) domains are essential
offloading enzymes, releasing covalently bound products from fatty acid, polyketide, and non …

Polyketides (PKs) are a large group of natural products produced by microorganisms and
plants. They are biopolymers of acetate and other short carboxylates and are biosynthesized …

The article discusses research on the development of a biocatalytic process for monacolin J
acid conversion into simvastatin acid. It acknowledges necessity of identifying a complete …

As a robust, fast growing and genetically tractable organism, the budding yeast
Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its …

The microbial synthesis of cannabinoids and related molecules requires access to the
intermediate olivetolic acid (OA). Whereas plant enzymes have been explored for E. coli and …

Resorcylic acid lactones are fungal polyketides that display diverse biological activities, with
the potent Hsp90 inhibitor radicicol being an important representative member. Two fungal …