Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

There is considerable evidence for induction of differential risk of noncommunicable
diseases in humans by variation in the quality of the early life environment. Studies in animal …

Diet during pregnancy influences the future health of a woman's offspring, with outcomes
differing depending on the child's sex. Because the placenta buffers the fetus from the …

Obesity is now epidemic worldwide. Beyond associated diseases such as diabetes, obesity
is linked to neuropsychiatric disorders such as depression. Alarmingly maternal obesity and …

Cardiovascular disease remains the number one killer in western nations in spite of declines
in death rates following improvements in clinical care. It has been 20 years since David …

Background Changes in imprinted gene dosage in the placenta may compromise the
prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to …

Males and females responses to gestational overnutrition set the stage for subsequent sex-
specific differences in adult onset non communicable diseases. Placenta, as a widely …

Undernutrition during pregnancy reduces birth weight and programmes adult phenotype
with consequences for life expectancy, but its effects on the phenotype of the placenta …