Abstract Design of experiment (DoE) is a powerful statistical technique used for variable
screening and optimization. It is based on the simultaneous variation of multiple factors with …

Although nano-immunotherapy has advanced dramatically in recent times, there remain two
significant hurdles related to immune systems in cancer treatment, such as (namely) …

Background Metastasis causes the most breast cancer-related deaths in women. Here, we
investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the …

Amongst the various microtubule-targeting agents, Docetaxel (DTX) has gained immense
attention in cancer chemotherapy due to its good therapeutic index. DTX belongs to the …

New polymeric systems are constantly developed for novel biomedical applications.
Pluronic F127 (PF127) is a tri-block copolymer with surface-active properties. It comprises a …

Pluronics are a class of amphiphilic tri-block copolymers with wide pharmaceutical
applicability. In the past decades, the ability to form biocompatible nanosized micelles was …

Syringic acid (SA), a natural polyphenol found in fruits and vegetables, is claimed to show
notable hepatoprotection. Nevertheless, low solubility and bioavailability hamper the …

Background Docetaxel (DTX) is an anticancer drug that is currently formulated with
polysorbate 80 and ethanol (50: 50, v/v) in clinical use. Unfortunately, this formulation …

Tumor-associated macrophages (TAMs) in the tumor microenvironment potentially enhance
tumor growth and invasion through various mechanisms and are thus an essential factor in …

Since the anticancer drugs exhibited a variety of inhibitory mechanisms in cancer cells, the
use of two or more anticancer drugs may have excellent therapeutic effects, particularly in …