Biological materials found in living organisms, many of which are proteins, feature a
complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in …

Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Current homogeneous bioscaffolds could hardly recapture the regenerative
microenvironment of extracellular matrix. Inspired by the peculiar nature of dura matter, we …

To address the growing need for corneal transplants two main approaches are being
pursued: allogenic and synthetic materials. Allogenic tissue from human donors is currently …

Corneal transplantation is an important surgical treatment for many common corneal
diseases. However, a worldwide shortage of tissue from suitable corneal donors has meant …

For the majority of patients with severe corneal injury or disease, corneal transplantation is
the only suitable treatment option. Unfortunately, the demand for donor corneas greatly …

Corneal diseases constitute the second leading cause of vision loss and affect more than 10
million people globally. As there is a severe shortage of fresh donated corneas and an …

The main obstacle to successfully engineering corneal tissue has been the replication of the
structural and biochemical composition of native cornea in a scaffold. In recent years …

In this project, we strived to develop a decellularized human cornea to use as a scaffold for
reconstructing the corneal epithelium and anterior stroma. Human cadaver corneas were …

Corneal diseases are the main reason of vision loss globally. Constructing a corneal
equivalent which has a similar strength and transparency with the native cornea, seems to …