A revolution occurred during the last decade in the comprehension of the physiology as well
as in the physiopathology of iron metabolism. The purpose of this review is to summarize the …

Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the
TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease …

A comprehensive discussion of haematological morphology In the newly revised Sixth
Edition of Blood Cells: A Practical Guide, expert haematologist Barbara J. Bain delivers a …

Iron is an essential metal for many biologic processes in mammals. Its primary role is to bind
oxygen in the heme moiety of hemoglobin. Iron also plays a central role in the enzymatic …

Matriptase-2, encoded by the TMPRSS6 gene, is a member of the type II transmembrane
serine protease family. Matriptase-2 has structural and enzymatic similarities to matriptase-1 …

TMPRSS6 variants that affect protein function result in impaired matriptase‐2 function and
consequently uninhibited hepcidin production, leading to iron refractory iron deficiency …

Iron refractory iron deficiency anemia (IRIDA) is a rare hereditary disease caused by
mutations in TMPRSS6 gene encoding Matriptase‐2, a negative regulator of hepcidin …

Iron resistance iron deficiency anaemia is a rare autosomal recessive disorder characterized
by hypochromic microcytic anaemia, low transferrin saturation and inappropriately high …

Objectives: We report a case of a 7-year-old girl with severe hypochromic microcytic anemia,
who was unresponsive to classical iron supplements. We suspected IRIDA, iron-refractory …

Iron deficiency anaemia (IDA) has been recognised as a common global health problem that
affects more than 1.2 billion people worldwide, particularly in high-risk individuals such as …