DNA methylation and schizophrenia: current literature and future perspective

T Magwai, KB Shangase, FO Oginga, B Chiliza… - Cells, 2021 - mdpi.com
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

Neurodevelopmental factors in schizophrenia

H Jaaro-Peled, A Sawa - Psychiatric Clinics, 2020 - psych.theclinics.com
Schizophrenia is known to be one of the most devastating and chronic mental conditions.
The onset of this syndrome, which includes heterogeneous subsets of disease conditions, is …

The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review

T Dahoun, SV Trossbach, NJ Brandon, C Korth… - Translational …, 2017 - nature.com
Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Bridging Autism Spectrum Disorders and Schizophrenia through inflammation and biomarkers-pre-clinical and clinical investigations

J Prata, SG Santos, MI Almeida, R Coelho… - Journal of …, 2017 - Springer
In recent years, evidence supporting a link between inflammation and neuropsychiatric
disorders has been mounting. Autism spectrum disorders (ASD) and schizophrenia share …

Understanding translational research in schizophrenia: a novel insight into animal models

JA Malik, Z Yaseen, L Thotapalli, S Ahmed… - Molecular Biology …, 2023 - Springer
Schizophrenia affects millions of people worldwide and is a major challenge for the scientific
community. Like most psychotic diseases, it is also considered a complicated mental …

A critical review of zebrafish schizophrenia models: time for validation?

K Gawel, NS Banono, A Michalak… - … & Biobehavioral Reviews, 2019 - Elsevier
Schizophrenia is a mental disorder that affects 1% of the population worldwide and is
manifested as a broad spectrum of symptoms, from hallucinations to memory impairment. It …

Cannabis use and mental illness: understanding circuit dysfunction through preclinical models

BW Jenkins, JY Khokhar - Frontiers in psychiatry, 2021 - frontiersin.org
Patients with a serious mental illness often use cannabis at higher rates than the general
population and are also often diagnosed with cannabis use disorder. Clinical studies reveal …

Neurobiology and treatment of social cognition in schizophrenia: Bridging the bed-bench gap

S Kimoto, M Makinodan, T Kishimoto - Neurobiology of disease, 2019 - Elsevier
Social cognition refers to the psychological processes involved in the perception, encoding,
storage, retrieval, and regulation of information about others and ourselves. This process is …

Transient knock-down of prefrontal DISC1 in immune-challenged mice causes abnormal long-range coupling and cognitive dysfunction throughout development

X Xu, M Chini, SH Bitzenhofer… - Journal of …, 2019 - Soc Neuroscience
Compromised brain development has been hypothesized to account for mental illness. This
concept was underpinned by the function of the molecule disrupted-in-schizophrenia 1 …

How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?

SJ Clapcote - Disease Models & Mechanisms, 2022 - journals.biologists.com
Schizophrenia is a serious mental illness affecting 0.7% of the world's population. Despite
over 50 years of schizophrenia drug identification and development, there have been no …