Macrophages, which have functions of engulfing and digesting foreign substances, can
clear away harmful matter, including cellular debris and tumor cells. Based on the condition …

Cell therapy approaches that employ engineered mammalian cells for on-demand
production of therapeutic agents in the patient's body are moving beyond proof-of-concept in …

T cells engineered to express chimeric antigen receptors (CARs) can recognize and engage
with target cancer cells with redirected specificity for cancer immunotherapy. However, there …

In solid tumours, the abundance of macrophages is typically associated with a poor
prognosis. However, macrophage clusters in tumour-cell nests have been associated with …

Synthetic molecular communication (MC) is a new communication engineering paradigm
which is expected to enable revolutionary applications such as smart drug delivery and real …

Despite its success in treating hematologic malignancies, chimeric antigen receptor (CAR) T
cell therapy faces two major challenges which hinder its broader applications: the limited …

Piezo1 belongs to mechano‐activatable cation channels serving as biological force sensors.
However, the molecular events downstream of Piezo1 activation remain unclear. In this …

Background Myocardial infarction (MI) is a serious cardiovascular disease with a poor
prognosis. Macrophages are the predominant immune cells in patients with MI and …

Orthogonal tools for controlling protein function by post-translational modifications open up
new possibilities for protein circuit engineering in synthetic biology. Phosphoregulation is a …

We now want to begin to develop a holistic view of cartilage as a tissue that has an
integrated set of homeostatic processes for maintaining itself. In the context of other tissues …