The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Increased dietary fiber consumption has been associated with many beneficial effects,
including amelioration of obesity and insulin resistance. These effects may be due to the …

Sarcopenia is a common muscular affection among elderly individuals. More recently, it has
been recognized as the skeletal muscle (SM) expression of the metabolic syndrome. The …

Objectives: This study sought to derive and validate plasma metabolite associations with
survival in heart failure (HF) patients. Background: Profiling of plasma metabolites to predict …

Blood contains powerful pH-buffering molecules such as hemoglobin (Hb) and albumin,
while interstitial fluids have little pH-buffering molecules. Thus, even under metabolic …

Obesity-induced fat ectopic deposition results in mitochondrial dysfunction and oxidative
stress in skeletal muscle, which could impair the quality and function of the skeletal muscle …

With the improvement of living standards and a change in lifestyle, the incidence of type 2
diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely …

Insulin therapy plays an essential role in the treatment of diabetes mellitus. However,
frequent injections required to effectively control the glycemic levels lead to substantial …

Cellular homeostasis in eukaryotic cells requires synchronized coordination of multiple
organelles. A key role in this stage is played by mitochondria, which have recently emerged …

Over two thousand proteins are found in the mitochondrial compartment but the
mitochondrial genome codes for only 13 proteins. The majority of mitochondrial proteins are …