Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease.
NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine …

In multicellular organisms, nutrient uptake and its metabolism are subject to stringent
regulation to maintain cellular integrity and prevent aberrant cell proliferation. However, the …

Background & Aims Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis,
strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. The current
treatment of HCC mainly includes surgery, chemotherapy, and liver transplantation. HCC …

Cell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited
to a small set of interconnected cell‐specific transcription factors (TFs). By mining global …

Conclusions: Many metabolic changes in cancer cells are shared by proliferating normal
hepatocytes in response to a hostile environment. Nrf2 activation is essential for bridging …

Introduction Several lines of evidence suggest that the thyroid hormone signaling pathway is
altered in patients with NAFLD and that pharmacological strategies to target the thyroid …

Context Circulating concentrations of free triiodothyronine (fT3), free thyroxine (fT4), and
thyrotropin (TSH) are partly heritable traits. Recent studies have advanced knowledge of …