Hydrazone linkages in pH responsive drug delivery systems
SJ Sonawane, RS Kalhapure, T Govender - European Journal of …, 2017 - Elsevier
Stimuli-responsive polymeric drug delivery systems using various triggers to release the
drug at the sites have become a major focus area. Among various stimuli-responsive …
drug at the sites have become a major focus area. Among various stimuli-responsive …
Applications of orthogonal “click” chemistries in the synthesis of functional soft materials
RK Iha, KL Wooley, AM Nystrom, DJ Burke… - Chemical …, 2009 - ACS Publications
Applications for advanced functional soft materials that possess precisely engineered
properties and functional groups have been expanding significantly with the development of …
properties and functional groups have been expanding significantly with the development of …
pH-and ion-sensitive polymers for drug delivery
T Yoshida, TC Lai, GS Kwon, K Sako - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: Drug delivery systems (DDSs) are important for effective, safe, and convenient
administration of drugs. pH-and ion-responsive polymers have been widely employed in …
administration of drugs. pH-and ion-responsive polymers have been widely employed in …
Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin
M Talelli, M Iman, AK Varkouhi, CJF Rijcken… - Biomaterials, 2010 - Elsevier
Doxorubicin (DOX) is clinically applied in cancer therapy, but its use is associated with dose
limiting severe side effects. Core-crosslinked biodegradable polymeric micelles composed …
limiting severe side effects. Core-crosslinked biodegradable polymeric micelles composed …
[HTML][HTML] HPMA copolymer-based nanomedicines in controlled drug delivery
Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy
Herein, new biodegradable star polymer–doxorubicin conjugates designed for passive
tumor targeting were investigated, and their synthesis, physico-chemical characterization …
tumor targeting were investigated, and their synthesis, physico-chemical characterization …
Poly (2-ethyl-2-oxazoline) conjugates with doxorubicin for cancer therapy: In vitro and in vivo evaluation and direct comparison to poly [N-(2-hydroxypropyl) …
O Sedlacek, BD Monnery, J Mattova, J Kucka, J Panek… - Biomaterials, 2017 - Elsevier
We designed and synthesized a new delivery system for the anticancer drug doxorubicin
based on a biocompatible hydrophilic poly (2-ethyl-2-oxazoline)(PEtOx) carrier with linear …
based on a biocompatible hydrophilic poly (2-ethyl-2-oxazoline)(PEtOx) carrier with linear …
Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting
L Li, Q Yang, Z Zhou, J Zhong, Y Huang - Biomaterials, 2014 - Elsevier
Although folate exhibits many advantages over other targeting ligands, it has one major
defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2 …
defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2 …
Intrinsically active nanobody-modified polymeric micelles for tumor-targeted combination therapy
M Talelli, S Oliveira, CJF Rijcken, EHE Pieters, T Etrych… - Biomaterials, 2013 - Elsevier
Various different passively and actively targeted nanomedicines have been designed and
evaluated over the years, in particular for the treatment of cancer. Reasoning that the …
evaluated over the years, in particular for the treatment of cancer. Reasoning that the …
The chemistry of bioconjugation in nanoparticles‐based drug delivery system
K Werengowska-Ciećwierz… - … in Condensed Matter …, 2015 - Wiley Online Library
Nanomedicine is, generally, the application of nanotechnology to medicine. The term
nanomedicine includes monitoring, construction of novel drug delivery systems, and any …
nanomedicine includes monitoring, construction of novel drug delivery systems, and any …