The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

Prevention of epileptogenesis after brain trauma is an unmet medical challenge. Recent
molecular profiling studies have provided an insight into molecular changes that contribute …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features …

Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Impaired GABA-mediated neurotransmission has been implicated in many neurologic
diseases, including epilepsy, intellectual disability and psychiatric disorders. We found that …

High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-
band, transient burst-like phenomenon or steady-state. HFOs may be encountered under …

The present study investigated the development of hyperexcitability and epilepsy in mice
with traumatic brain injury (TBI) induced by controlled cortical impact (CCI) or lateral fluid …

High-frequency oscillations (HFOs; 80–500 Hz) are thought to mirror the pathophysiological
changes occurring in epileptic brains. However, the distribution of HFOs during seizures …

The generation of interictal epileptiform discharges (IEDs) in partial epilepsies is commonly
ascribed to enhanced excitatory interactions within glutamatergic neuronal networks. Recent …

Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy and
several rodent models allow studying the pathophysiology of this disorder. One of the best …