FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Introduction: Despite advancements over the last 2 years, outcomes for acute myeloid
leukemia (AML) are poor; however, a greater comprehension of disease mechanisms has …

Acute myeloid leukemia (AML) is a complex disease with an aggressive clinical course and
high mortality rate. The standard of care for patients has only changed minimally over the …

Abstract RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid
leukaemia. Seminal contributions by many different research groups have revealed a …

Background Acute myeloid leukemia (AML) is the most common type of adult leukemia.
Several studies have demonstrated that oncogenesis in AML is enhanced by kinase …

Protein tyrosine kinases have been recognized as important actors of cell transformation
and cancer progression, since their discovery as products of viral oncogenes. SRC-family …

The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic
compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of …

The multitargeted protein kinase inhibitor midostaurin is approved for the treatment of both
newly diagnosed FLT3-mutated acute myeloid leukemia (AML) and KIT-driven advanced …

Abstract Background: Leukaemia stem cells (LSCs) are responsible for the initiation,
maintenance, and recurrence of acute myeloid leukaemia (AML), an aggressive …

CSF1R is a receptor tyrosine kinase responsible for the growth/survival/polarization of
macrophages and overexpressed in some AML patients. We hypothesized that a novel multi …