Epilepsy is one of the most common neurological diseases worldwide. Anti-seizure
medications (ASMs) with anticonvulsants remain the mainstay of epilepsy treatment …

Experimental studies reveal that caffeine (trimethylxanthine) at subconvulsive doses,
distinctly reduced the anticonvulsant activity of numerous antiseizure medications (ASMs) in …

Astrocytes, the most abundant cells in the brain, are integral to sleep regulation. In the
context of a healthy neural environment, these glial cells exert a profound influence on the …

Abstract Background and Purpose Adenosine, through the A1 receptor (A1R), is an
endogenous anticonvulsant. The development of adenosine receptor agonists as …

Approximately 30% of patients with epilepsy are drug-refractory. There is an urgent need to
elucidate the exact pathophysiology of different types of epilepsies and the mechanisms of …

Seizures are generally associated with epilepsy but may also be a symptom of many other
neurological conditions. A hallmark of a seizure is the intensity of the local neuronal …

Rationale Evidence of the effects of chronic caffeine (CAFF)-containing beverages, alone or
in combination with agomelatine (AGO) or quetiapine (QUET), on electroencephalography …

Epileptic seizures can be dangerous as they cause sudden and uncontrolled electrical
activity in the brain which can lead to injuries if one falls or loss of control over physical …

Objective The study investigates whether the expression and function of ENT1 can be
regulated by inhibiting the JNK signaling pathway, thereby altering the levels of extracellular …

There are limited therapeutic options for patients with Dravet syndrome (DS). The
equilibrative nucleoside transporters 1 (ENT1) mediate both the influx and efflux of …