Organic reactions in microdroplets: reaction acceleration revealed by mass spectrometry
The striking finding that reaction acceleration occurs in confined‐volume solutions sets up
an apparent conundrum: Microdroplets formed by spray ionization can be used to monitor …
an apparent conundrum: Microdroplets formed by spray ionization can be used to monitor …
Ambient ionization mass spectrometry for point-of-care diagnostics and other clinical measurements
BACKGROUND One driving motivation in the development of point-of-care (POC)
diagnostics is to conveniently and immediately provide information upon which healthcare …
diagnostics is to conveniently and immediately provide information upon which healthcare …
Accelerated reactions of amines with carbon dioxide driven by superacid at the microdroplet interface
Microdroplets display distinctive interfacial chemistry, manifested as accelerated reactions
relative to those observed for the same reagents in bulk. Carbon dioxide undergoes C–N …
relative to those observed for the same reagents in bulk. Carbon dioxide undergoes C–N …
A critical analysis of electrospray techniques for the determination of accelerated rates and mechanisms of chemical reactions in droplets
Electrospray and Electrosonic Spray Ionization Mass Spectrometry (ESI-MS and ESSI-MS)
have been widely used to report evidence that many chemical reactions in micro-and nano …
have been widely used to report evidence that many chemical reactions in micro-and nano …
Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids
We report a metal-free novel route for the accelerated synthesis of benzimidazole and its
derivatives in the ambient atmosphere. The synthetic procedure involves 1, 2-aromatic …
derivatives in the ambient atmosphere. The synthetic procedure involves 1, 2-aromatic …
High throughput reaction screening using desorption electrospray ionization mass spectrometry
We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …
handling routines that were originally developed for biological tissue imaging. Desorption …
Accelerated Hantzsch electrospray synthesis with temporal control of reaction intermediates
Complex chemical reactions can occur in electrosprayed droplets on the millisecond time
scale. The Hantzsch synthesis of 1, 4-dihydropyridines was studied in this way using on-line …
scale. The Hantzsch synthesis of 1, 4-dihydropyridines was studied in this way using on-line …
Ambient mass spectrometry imaging using direct liquid extraction techniques
J Laskin, I Lanekoff - Analytical chemistry, 2016 - ACS Publications
Mass spectrometry imaging (MSI) is a powerful analytical technique that enables label-free
spatial localization and identification of molecules in complex samples. 1− 4 MSI …
spatial localization and identification of molecules in complex samples. 1− 4 MSI …
Reaction acceleration in electrospray droplets: size, distance, and surfactant effects
Phenylhydrazone formation from isatin is used to examine the effects on the reaction rate of
(i) electrospray emitter distance from the mass spectrometer (MS) inlet,(ii) emitter tip …
(i) electrospray emitter distance from the mass spectrometer (MS) inlet,(ii) emitter tip …
Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids
AJ Ingram, CL Boeser, RN Zare - Chemical science, 2016 - pubs.rsc.org
There has been a burst in the number and variety of available ionization techniques to use
mass spectrometry to monitor chemical reactions in and on liquids. Chemists have gained …
mass spectrometry to monitor chemical reactions in and on liquids. Chemists have gained …