Brainstem gliomas are molecularly heterogeneous diseases, many of which are difficult to
safely surgically resect and have limited treatment options due to their eloquent location …

This clinical trial evaluated whether whole exome sequencing (WES) and RNA sequencing
(RNAseq) of paired normal and tumor tissues could be incorporated into a personalized …

Background: H3 K27M mutation was originally described in pediatric diffuse intrinsic pontine
gliomas (DIPGs), but has been recently recognized to occur also in adult midline diffuse …

In recent years, molecular profiling has led to the discovery of an increasing number of brain
tumor subtypes, and associated therapeutic targets. These molecular features have been …

OBJECTIVE H3 K27M-mutant gliomas present heterogeneously in terms of pathology,
imaging, and prognosis. This study aimed to summarize the imaging characteristics of adult …

Pediatric diffuse midline glioma is a highly morbid glial neoplasm that may arise in the
thalamus or brainstem (also known as diffuse intrinsic pontine glioma or DIPG). Because …

Purpose Accumulating evidence indicates that dysregulated long noncoding RNAs
(lncRNAs) play critical roles in tumorigenesis and cancer progression. LncRNA-maternally …

Posterior fossa group A ependymomas (EPN_PFA) are characterized by a loss of H3 K27
trimethylation due to either EZHIP overexpression or H3 p. K27M mutation, similar to H3 K27 …

Background Diffuse midline gliomas (DMG) are highly malignant incurable pediatric brain
tumors. A lack of effective treatment options highlights the need to investigate novel …

Abstract Purpose H3K27M mutant diffuse midline gliomas (DMGs) are considered grade IV
irrespective of histological features and have dismal prognosis. We evaluated clinico …