Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed
circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen …

Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic
diseases in neonates, infants, and older children and contributes to significant morbidity and …

Despite recent advances in the perinatal management of neonatal respiratory distress
syndrome (RDS), controversies still exist. We report updated recommendations of a …

Rationale: Recessive mutations in the ATP-binding cassette transporter A3 (ABCA3) cause
lethal neonatal respiratory failure and childhood interstitial lung disease. Most ABCA3 …

Pulmonary surfactant is a complex mixture of phospholipids (PL) and proteins (SP) that
reduce surface tension at the air–liquid interface of the alveolus. It is made up of about 70 …

Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …

Results from birth cohort and cross-sectional studies of young children with wheezing have
uncovered strong associations between both lung function and immune responses in early …

Monogenic lung diseases that are caused by mutations in surfactant genes of the pulmonary
epithelium are marked by perinatal lethal respiratory failure or chronic diffuse parenchymal …

Persistence of pulmonary hypertension leading to respiratory failure in the neonate has
been recognized for 40 years since its original description by Gersony and colleagues 1 in …