[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
[HTML][HTML] The γc family of cytokines: basic biology to therapeutic ramifications
WJ Leonard, JX Lin, JJ O'Shea - Immunity, 2019 - cell.com
The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …
Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia
MM Berrien-Elliott, JA Foltz… - Science translational …, 2022 - science.org
Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …
HLA informs risk predictions after haploidentical stem cell transplantation with posttransplantation cyclophosphamide
EJ Fuchs, SR McCurdy, SR Solomon… - Blood, The Journal …, 2022 - ashpublications.org
Hematopoietic cell transplantation from HLA-haploidentical related donors is increasingly
used to treat hematologic cancers; however, characteristics of the optimal haploidentical …
used to treat hematologic cancers; however, characteristics of the optimal haploidentical …
[HTML][HTML] Decrease post-transplant relapse using donor-derived expanded NK-cells
In this phase I/II clinical trial, we investigated the safety and efficacy of high doses of mb-IL21
ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with myeloid …
ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with myeloid …
Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning
SR McCurdy, V Radojcic, HL Tsai… - Blood, The Journal …, 2022 - ashpublications.org
The key immunologic signatures associated with clinical outcomes after posttransplant
cyclophosphamide (PTCy)-based HLA-haploidentical (haplo) and HLA-matched bone …
cyclophosphamide (PTCy)-based HLA-haploidentical (haplo) and HLA-matched bone …
[HTML][HTML] Post-transplant cyclophosphamide for graft-versus-host disease prophylaxis in HLA matched sibling or matched unrelated donor transplant for patients with …
A Ruggeri, M Labopin, A Bacigalupo… - Journal of hematology & …, 2018 - Springer
Background Experience using post-transplant cyclophosphamide (PT-Cy) as graft-versus-
host disease (GVHD) prophylaxis in allogeneic stem cell transplantation (HSCT) from …
host disease (GVHD) prophylaxis in allogeneic stem cell transplantation (HSCT) from …
The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell …
The number of HLA-haploidentical hematopoietic cell transplants continues to increase
worldwide due to recent improvements in outcomes, allowing more patients with …
worldwide due to recent improvements in outcomes, allowing more patients with …
Impaired T-and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide
B Rambaldi, HT Kim, C Reynolds… - Blood …, 2021 - ashpublications.org
Administration of posttransplant cyclophosphamide (PTCy) has significantly expanded the
number of patients undergoing HLA-haploidentical hematopoietic cell transplantation (haplo …
number of patients undergoing HLA-haploidentical hematopoietic cell transplantation (haplo …
[HTML][HTML] Adaptive NK cell response to human cytomegalovirus: facts and open issues
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system.
These include the differentiation and persistent expansion of a mature NK cell subset which …
These include the differentiation and persistent expansion of a mature NK cell subset which …