Compound activity prediction with dose-dependent transcriptomic profiles and deep learning
WJ Godinez, V Trifonov, B Fang, G Kuzu… - Journal of Chemical …, 2024 - ACS Publications
Predicting compound activity in assays is a long-standing challenge in drug discovery.
Computational models based on compound-induced gene expression signatures from a …
Computational models based on compound-induced gene expression signatures from a …
Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity
TW Gant, SS Auerbach, M Von Bergen, M Bouhifd… - Archives of …, 2023 - Springer
In a joint effort involving scientists from academia, industry and regulatory agencies,
ECETOC's activities in Omics have led to conceptual proposals for:(1) A framework that …
ECETOC's activities in Omics have led to conceptual proposals for:(1) A framework that …
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation
Adaptive stress response pathways (SRPs) restore cellular homeostasis following
perturbation but may activate terminal outcomes like apoptosis, autophagy, or cellular …
perturbation but may activate terminal outcomes like apoptosis, autophagy, or cellular …
Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes
MM Heintz, WD Klaren, AW East, LC Haws… - Toxicological …, 2024 - academic.oup.com
Like many per-or polyfluorinated alkyl substances (PFAS), toxicity studies with HFPO-DA
(ammonium, 2, 3, 3, 3-tetrafluoro-2-(heptafluoropropoxy)-propanoate), a short-chain PFAS …
(ammonium, 2, 3, 3, 3-tetrafluoro-2-(heptafluoropropoxy)-propanoate), a short-chain PFAS …
Completion of the DrugMatrix Toxicogenomics Database using ToxCompl
G Cong, RM Patton, F Chao, DL Svoboda, WM Casey… - bioRxiv, 2024 - biorxiv.org
The DrugMatrix Database contains systematically generated toxicogenomics data from short-
term in vivo studies for over 600 chemicals. However, most of the potential endpoints in the …
term in vivo studies for over 600 chemicals. However, most of the potential endpoints in the …
[PDF][PDF] Applying genomics in regulatory toxicology
TW Gant, SS Auerbach, M Von Bergen, M Bouhifd… - 2023 - pure-oai.bham.ac.uk
In a joint effort involving scientists from academia, industry and regulatory agencies,
ECETOC's activities in Omics have led to conceptual proposals for:(1) A framework that …
ECETOC's activities in Omics have led to conceptual proposals for:(1) A framework that …