[HTML][HTML] High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
Targeting cancer vulnerabilities with high-dose vitamin C
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
[HTML][HTML] O2⋅− and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate
JD Schoenfeld, ZA Sibenaller, KA Mapuskar… - Cancer cell, 2017 - cell.com
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when
combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are …
combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are …
[HTML][HTML] Cellular stress responses in radiotherapy
Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …
Oxidative stress
Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …
biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative …
[HTML][HTML] Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy
CM Doskey, V Buranasudja, BA Wagner, JG Wilkes… - Redox biology, 2016 - Elsevier
Ascorbate (AscH−) functions as a versatile reducing agent. At pharmacological doses (P-
AscH−;[plasma AscH−]≥≈ 20 mM), achievable through intravenous delivery, oxidation of P …
AscH−;[plasma AscH−]≥≈ 20 mM), achievable through intravenous delivery, oxidation of P …
Vitamin C in stem cell reprogramming and cancer
Vitamin C is an essential dietary requirement for humans. In addition to its known role as an
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …
antioxidant, vitamin C is a cofactor for Fe 2+-and α-ketoglutarate-dependent dioxygenases …
Polarization of tumor-associated macrophages promoted by vitamin C-loaded liposomes for cancer immunotherapy
While checkpoint blockade immunotherapy as a promising clinical modality has
revolutionized cancer treatment, it is of benefit to only a subset of patients because of the …
revolutionized cancer treatment, it is of benefit to only a subset of patients because of the …
Exercise as adjunct therapy in cancer
Data from observational studies indicate that both physical activity as well as exercise (ie,
structured physical activity) is associated with reductions in the risk of recurrence and cancer …
structured physical activity) is associated with reductions in the risk of recurrence and cancer …
[HTML][HTML] Epigenetic regulation of genomic stability by vitamin C
JP Brabson, T Leesang, S Mohammad… - Frontiers in genetics, 2021 - frontiersin.org
DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …