Primary cilia protrude from most vertebrate cell bodies and act as specialized 'signalling
antennae'that can substantially lengthen or retract in minutes to hours in response to specific …

A subset of genetic disorders termed ciliopathies are associated with obesity. The
mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes …

Disruption of ciliary homeostasis in vascular endothelial cells has been implicated in the
development of atherosclerosis. However, the molecular basis for the regulation of …

Various health issues have emerged due to consuming high-fat diets (HFD), particularly the
detrimental impact they have on mitochondrial dynamics and subsequet cognition functions …

High serum level of palmitic acid (PA) is implicated in pathogenesis of cardiovascular
diseases. PA serves as the substrate for protein palmitoylation. However, it is still unknown …

BACKGROUND: The ability to respond to mechanical forces is a basic requirement for
maintaining endothelial cell (ECs) homeostasis, which is continuously subjected to low …

(1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to
prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. The aim …

Background Research on the imbalance of proopiomelanocortin (POMC)/agouti-related
protein (AgRP) neurons in the hypothalamus holds potential insights into the …

Microglia cells are activated in response to different stress signals. Several metabolic
adaptations underlie microglia activation in the brain. Among these, in conditions like …

The brain is, after the adipose tissue, the organ with the greatest amount of lipids and
diversity in their composition in the human body. In neurons, lipids are involved in signaling …