Overview of antimicrobial resistance: an emerging silent pandemic

M Paneri, P Sevta - Global Journal of Medical, Pharmaceutical, and …, 2023 - gjmpbu.org
Before the outbreak of Coronavirus disease-19, one of the top 10 most risks identified by the
World Health Organization (WHO) is antimicrobial resistance (AMR) that is also known as …

[HTML][HTML] Clavulanic Acid Overproduction: A Review of Environmental Conditions, Metabolic Fluxes, and Strain Engineering in Streptomyces clavuligerus

D Gómez-Ríos, LM Gómez-Gaona, H Ramírez-Malule - Fermentation, 2024 - mdpi.com
Clavulanic acid is a potent β-lactamase inhibitor produced by Streptomyces clavuligerus,
widely used in combination with β-lactam antibiotics to combat antimicrobial resistance. This …

[HTML][HTML] Tuning of fed-batch cultivation of Streptomyces clavuligerus for enhanced Clavulanic Acid production based on genome-scale dynamic modeling

D Gómez-Ríos, H Ramírez-Malule, P Neubauer… - Biochemical …, 2022 - Elsevier
Streptomyces clavuligerus (S. clavuligerus) is a filamentous Gram-positive bacterial
producer of the β-lactamase inhibitor clavulanic acid (CA). Antibiotics biosynthesis and …

Evaluation of clavulanic acid recovery techniques from Streptomyces clavuligerus cultivation broths

Y Agudelo-Arenas, R Ríos-Estepa… - Journal of Applied …, 2024 - japsonline.com
Clavulanic acid (CA) is a soft β-lactam antibiotic with a strong inhibitory effect on β-
lactamase enzymes and it is produced by the filamentous Gram-positive bacterium …

[PDF][PDF] Flux dynamics of C-5 amino acid precursors in fed-batch cultures of Streptomyces clavuligerus during clavulanic acid biosynthesis

LM Gómez-Gaona, H Ramírez-Malule… - Journal of Applied …, 2024 - japsonline.com
Clavulanic acid (CA) is a well-known β-lactamase inhibitor that is mainly obtained from
submerged cultures of Streptomyces clavuligerus. Dynamic genome-scale in silico studies …

Dynamic in silico assessment of potential gene targets for enhancing clavulanic acid production in Streptomyces clavuligerus submerged cultures

D Gómez-Ríos, H Ramírez-Malule… - Journal of Applied …, 2023 - japsonline.com
Clavulanic acid (CA) is an antibiotic of the β-lactam class with moderate antimicrobial activity
but a high inhibitory effect on β-lactamase enzymes. CA is one of the most important …