Fluorine-containing amino acids are becoming increasingly prominent in new drugs due to
two general trends in the modern pharmaceutical industry. Firstly, the growing acceptance of …

Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Cyclic imines, in which the C [DOUBLE BOND] N bond is constrained in the Z geometry,
have been identified as highly effective substrates for enantioselective rhodium-catalyzed …

A novel Cu-catalyzed enantioselective decarboxylative Mannich reaction of cyclic aldimines
with β-ketoacids is described. The cyclic structure of these aldimines, in which the C N …

An enantioselective decarboxylative Mannich reaction of malonic acid half esters (MAHEs)
with cyclic aldimines has been accomplished by employing the copper (I)/(R, R)-Ph-Box …

An in situ generated photoactive copper (I)‐complex‐catalyzed aziridination reaction of
cyclic N‐sulfonyl imines with α‐aryl‐substituted vinyl azides irradiated by blue‐LEDs light is …

Replacement of the core β-amino acid in our previously reported piperidine acetic acid and
β-phenylalanine-based Bradykinin B1 antagonists by dihydroquinoxalinone acetic acid …

The Kinin Family. Kinins are naturally occurring vasoactive peptide hormones, which are
known to be important mediators of a variety of biological effects, including cardiovascular …

The bradykinin B1 receptor is rapidly induced upon tissue injury and inflammation,
stimulating the production of inflammatory mediators resulting in plasma extravasation …

Background: For> 20 years, pharmaceutical companies and academic centers have been
developing bradykinin antagonists. The patent literature on these molecules (up to and …