Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …

Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …

Highlights•Not all IDRs undergo liquid–liquid phase separation.•IDRs are not necessary for
protein phase separation.•A stickers-and-spacers framework helps conceptualizing IDR …

Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …

Highlights•Liquid-liquid phase separation underlies the formation of membraneless
organelles within cells.•Theory and molecular simulations help to relate interactions at the …

The chemical design of polymers with target structural and/or functional properties
represents a grand challenge in materials science. While data-driven design approaches …

Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a
range of functional roles. While folded domains are generally well-described by a stable 3D …

The protein folding problem was first articulated as question of how order arose from
disorder in proteins: How did the various native structures of proteins arise from interatomic …