Importance Deficiency of adenosine deaminase 2 (DADA2) is a recessively inherited
disease characterized by systemic vasculitis, early-onset stroke, bone marrow failure, and/or …

Deficiency of adenosine deaminase 2 (DADA2) was first described as a monogenic form of
systemic vasculitis that closely resembles polyarteritis nodosa (PAN). The phenotypic …

The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited
disease that has undergone extensive phenotypic expansion since being first described in …

The understanding of immune dysregulation in many different diseases continues to grow.
There is increasing evidence that altered microbiome and gut barrier dysfunction contribute …

Purpose Deficiency of adenosine deaminase type 2 (ADA2)(DADA2) is a rare inborn error of
immunity caused by deleterious biallelic mutations in ADA2. Clinical manifestations are …

Deficiency of adenosine deaminase type 2 (DADA2) was first described in 2014 as a
monogenic cause of polyartertitis nodosa (PAN), early onset lacunar stroke and livedo …

Autoimmunity may be a manifestation of inborn errors of immunity, specifically as part of the
subgroup of primary immunodeficiency known as primary immune regulatory disorders …

Deficiency of adenosine deaminase 2 (DADA2) is an inherited autosomal recessive disease
characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa …

Deficiency of adenosine deaminase type 2 (DADA2) is an autosomal recessive disease
caused by bi-allelic loss-of-function mutations in ADA2. Treatment with anti-TNF is effective …

Introduction Primary immune regulatory disorders encompass a range of clinical conditions
caused by different defects of immune regulatory mechanisms, including systemic …