The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Covering: 1994 to 2020 Retinoic acid receptor-related orphan receptors (RORs) belong to a
subfamily of the nuclear receptor superfamily and possess prominent roles in circadian …

In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …

Background Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer's
disease (AD), yet numerous studies have demonstrated a beneficial role for …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes a committed and rate-limiting step
in hepatic gluconeogenesis, and its activity is tightly regulated to maintain blood glucose …

Nuclear hormone receptors have important roles in the regulation of metabolic and
inflammatory pathways. The retinoid-related orphan receptor alpha (Rorα)-deficient …

Members of the claudin family play important roles in the formation of tight junctions (TJs) in
several tissues. Claudin domain containing 1 (CLDND1) is homologous to this family and …

Mechanisms underlying neuropathic pain (NP) are complex with multiple genes, their
interactions, environmental and epigenetic factors being implicated. Transcriptional changes …

Background Neutral cholesterol ester hydrolase 1 (NCEH1) catalyzes the hydrolysis of
cholesterol ester (CE) in macrophages. Genetic ablation of NCEH1 promotes CE-laden …