[HTML][HTML] Calcium signaling in Alzheimer's disease & therapies

BCK Tong, AJ Wu, M Li, KH Cheung - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Mitochondrial aspects of synaptic dysfunction in Alzheimer's disease

Q Cai, P Tammineni - Journal of Alzheimer's disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …

The role of glutamate in neuronal ischemic injury: the role of spark in fire

BB Kostandy - Neurological Sciences, 2012 - Springer
Although being a physiologically important excitatory neurotransmitter, glutamate plays a
pivotal role in various neurological disorders including ischemic neurological diseases. Its …

Delineation of neuroprotective effects and possible benefits of antioxidantstherapy for the treatment of Alzheimer's diseases by targeting mitochondrial-derived …

V Walia, D Kaushik, V Mittal, K Kumar, R Verma… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is considered the sixth leading cause of death in elderly patients
and is characterized by progressive neuronal degeneration and impairment in memory …

Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities

JT Yu, RCC Chang, L Tan - Progress in neurobiology, 2009 - Elsevier
Calcium is involved in many facets of neuronal physiology, including activity, growth and
differentiation, synaptic plasticity, and learning and memory, as well as pathophysiology …

Neurotransmitters in the mediation of cerebral ischemic injury

D Mayor, M Tymianski - Neuropharmacology, 2018 - Elsevier
Under physiological conditions, neurotransmitters shape neuronal networks and control
several cellular and synaptic functions. In the mammalian central nervous system (CNS) …

The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia

FM Benes, D Matzilevich, RE Burke, J Walsh - Molecular psychiatry, 2006 - nature.com
Post-mortem studies conducted over the past 15 years suggest that apoptosis could play a
role in the pathophysiology of bipolar disorder (BD) and, to a lesser degree, schizophrenia …

Association between chronic kidney disease and Alzheimer's disease: an update

CY Zhang, FF He, H Su, C Zhang, XF Meng - Metabolic Brain Disease, 2020 - Springer
It has been accepted that kidney function is connected with brain activity. In clinical studies,
chronic kidney disease (CKD) patients have been found to be prone to suffering cognitive …

Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats

S Sonkusare, K Srinivasan, C Kaul, P Ramarao - Life Sciences, 2005 - Elsevier
Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in
rats. ICV STZ is known to impair cholinergic neurotransmission by decreasing choline …

The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases

GY Sun, LA Horrocks, AA Farooqui - Journal of neurochemistry, 2007 - Wiley Online Library
Reactive oxygen species (ROS) are produced in mammalian cells through enzymic and non‐
enzymic mechanisms. Although some ROS production pathways are needed for specific …