Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and
gender. The mechanisms by which sex and gender work alone and in combination with …

Serine is a key contributor to the generation of one-carbon units for DNA synthesis during
cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that …

Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for
cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 …

Fluorouracil (5-FU) is a key component of chemotherapy for colorectal cancer (CRC). 5-FU
efficacy is established by intracellular levels of folate cofactors and DNA damage repair …

Molecular classification of gastric cancer (GC) identified a subgroup of patients showing
chemoresistance and poor prognosis, termed SEM (Stem-like/Epithelial-to-mesenchymal …

The intake of dietary protein regulates growth, metabolism, fecundity and lifespan across
various species, which makes amino acid (AA)-sensing vital for adaptation to the nutritional …

One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several
amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the …

The integrated stress response (ISR) refers to signaling pathways initiated by stress-
activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including …

Background One-third of cancers activate endogenous synthesis of serine/glycine, and can
become addicted to this pathway to sustain proliferation and survival. Mechanisms driving …

Serine has functions that are involved in metabolic homeostasis and health in pathological
or stressful situations. Notably, the de novo serine synthesis pathway (SSP) plays a vital role …