Departments of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical
School, Tokyo, Japan Colorectal cancer (CRC) is the third most common cancer worldwide …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

An international panel of multidisciplinary experts convened to develop recommendations
for the management of patients with liver metastases from colorectal cancer (CRC). The aim …

Background: Liver metastases present with distinct histopathological growth patterns
(HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs …

Abstract Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer
(CRC) by in situ immunohistochemical staining supports the hypothesis that the adaptive …

Personalized cancer medicine based on the genetic milieu of individual colorectal tumors
has long been postulated, but until recently this concept was not supported by clinical …

Background This population-based study investigated the frequency of hepatic resections
for colorectal cancer metastases across England and their outcome. Methods Individuals …

The past 5 years have seen the clear recognition that the administration of chemotherapy to
patients with initially unresectable colorectal liver metastases can increase the number of …

Purpose: Circulating cell-free DNA (ccfDNA) is a valuable source of tumor material obtained
from a simple blood sampling that enables noninvasive analysis of the tumor genome. Our …

Context.—Colorectal cancer is the leading cause of morbidity and death among
gastrointestinal tumors and ranks fourth after lung, breast, and ovarian cancers. Despite a …