Gene evolution has long been thought to be primarily driven by duplication and
rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes …

Why do proteins evolve at different rates? Advances in systems biology and genomics have
facilitated a move from studying individual proteins to characterizing global cellular factors …

Understanding the genetic regulatory code governing gene expression is an important
challenge in molecular biology. However, how individual coding and non-coding regions of …

One of the major properties of genes is their expression pattern. Notably, genes are often
classified as tissue specific or housekeeping. This property is of interest to molecular …

The generation of mathematical models of biological processes, the simulation of these
processes under different conditions, and the comparison and integration of multiple data …

The copepod Tigriopus californicus shows extensive population divergence and is
becoming a model for understanding allopatric differentiation and the early stages of …

Strikingly consistent correlations between rates of coding-sequence evolution and gene
expression levels are apparent across taxa, but the biological causes behind the selective …

Much recent work has explored molecular and population-genetic constraints on the rate of
protein sequence evolution. The best predictor of evolutionary rate is expression level, for …

The NCI-60 cell line collection is a very widely used panel for the study of cellular
mechanisms of cancer in general and in vitro drug action in particular. It is a model system …

A gene's rate of sequence evolution is among the most fundamental evolutionary quantities
in common use, but what determines evolutionary rates has remained unclear. Here, we …