Understanding and overcoming resistance to PARP inhibitors in cancer therapy

MP Dias, SC Moser, S Ganesan… - Nature reviews Clinical …, 2021 - nature.com
Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …

Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks

H Yang, S Ren, S Yu, H Pan, T Li, S Ge… - International journal of …, 2020 - mdpi.com
Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …

Mammalian RAD52 functions in break-induced replication repair of collapsed DNA replication forks

SK Sotiriou, I Kamileri, N Lugli, K Evangelou, C Da-Ré… - Molecular cell, 2016 - cell.com
Human cancers are characterized by the presence of oncogene-induced DNA replication
stress (DRS), making them dependent on repair pathways such as break-induced …

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

F Pâques, JE Haber - Microbiology and molecular biology reviews, 1999 - Am Soc Microbiol
The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

Pathways of DNA double-strand break repair during the mammalian cell cycle

K Rothkamm, I Krüger, LH Thompson… - Molecular and cellular …, 2003 - Taylor & Francis
Little is known about the quantitative contributions of nonhomologous end joining (NHEJ)
and homologous recombination (HR) to DNA double-strand break (DSB) repair in different …

[HTML][HTML] Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of …

M Takata, MS Sasaki, E Sonoda, C Morrison… - The EMBO …, 1998 - embopress.org
Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways,
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …

Chromosomal stability and the DNA double-stranded break connection

DC Van Gent, JHJ Hoeijmakers, R Kanaar - Nature Reviews Genetics, 2001 - nature.com
Genome stability is of primary importance for the survival and proper functioning of all
organisms. Double-stranded breaks in DNA are important threats to genome integrity …

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

P Sung, H Klein - Nature reviews Molecular cell biology, 2006 - nature.com
Homologous recombination (HR) is an important mechanism for the repair of damaged
chromosomes, for preventing the demise of damaged replication forks, and for several other …

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

LS Symington - Microbiology and molecular biology reviews, 2002 - Am Soc Microbiol
The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …