Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …

Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …

Human cancers are characterized by the presence of oncogene-induced DNA replication
stress (DRS), making them dependent on repair pathways such as break-induced …

The budding yeast Saccharomyces cerevisiae has been the principal organism used in
experiments to examine genetic recombination in eukaryotes. Studies over the past decade …

Little is known about the quantitative contributions of nonhomologous end joining (NHEJ)
and homologous recombination (HR) to DNA double-strand break (DSB) repair in different …

Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways,
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …

Genome stability is of primary importance for the survival and proper functioning of all
organisms. Double-stranded breaks in DNA are important threats to genome integrity …

Homologous recombination (HR) is an important mechanism for the repair of damaged
chromosomes, for preventing the demise of damaged replication forks, and for several other …

The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …