Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the
precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this …

Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism.
This phenomenon, known as the Warburg effect, is critical for tumor development. However …

Metastases remain the major cause of death from cancer. Recent molecular advances have
highlighted the importance of metabolic alterations in cancer cells, including the Warburg …

Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in
human cells. However, the characterization, regulatory mechanism and functional …

Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post‐
translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone …

The pentose phosphate pathway (PPP) plays a critical role in macromolecule biosynthesis
and maintaining cellular redox homoeostasis in rapidly proliferating cells. Upregulation of …

Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen.
Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is …

Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal
adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary …

Background Osteosarcoma (OS) is a malignant tumor mainly occurring in young people.
Due to the limited effective therapeutic strategies, OS patients cannot achieve further …