Mass-spectrometry-based proteomics is continuing to make major contributions to the
discovery of fundamental biological processes and, more recently, has also developed into …

Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Background Constraint-based analysis of genome-scale metabolic models typically relies
upon maximisation of a cellular objective function such as the rate or efficiency of biomass …

We present an experimental and computational pipeline for the generation of kinetic models
of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …

Although bulk protein turnover has been measured with the use of stable isotope labeled
tracers for over half a century, it is only recently that the same approach has become …

As a fundamental energy-conserving process common to all living organisms, respiration is
responsible for the oxidation of respiratory substrates to drive ATP synthesis. Accordingly, it …

Quantifying cellular components is a basic and important step for understanding how a cell
works, how it responds to environmental changes, and for re-engineering cells to produce …