Protection against microbial infection in eukaryotes is provided by diverse cellular and
molecular mechanisms. Here, we present a comparative view of the antiviral activity of virus …

Highlights•RNAi is an important antiviral defense mechanism in insects.•All major classes of
viruses are targets of the antiviral RNAi response.•Viruses encode suppressors that interfere …

One important discovery in plant pathology over recent decades is the natural antiviral
defense mechanism mediated by RNA interference (RNAi). In antiviral RNAi, virus infection …

Highlights•Insect RNA interference (RNAi) pathways detect and restrict viruses.•Dicer-2
detects diverse viral dsRNA signatures and initiates the RNAi pathway.•RNAi may play a …

Influenza A virus (IAV) causes annual epidemics and occasional pandemics, and is one of
the best-characterized human RNA viral pathogens 1. However, a physiologically relevant …

The fruit fly Drosophila melanogaster has been a valuable model to investigate the genetic
mechanisms of innate immunity. Initially focused on the resistance to bacteria and fungi …

The RNA interference (RNAi) pathway is a potent antiviral defense mechanism in plants and
invertebrates, in response to which viruses evolved suppressors of RNAi. In mammals, the …

Invertebrates rely on Dicer to cleave viral double-stranded RNA (dsRNA), and Drosophila
Dicer-2 distinguishes dsRNA substrates by their termini. Blunt termini promote processive …

Virus surveillance in vector insects is potentially of great benefit to public health. Large-scale
sequencing of small and long RNAs has previously been used to detect viruses, but without …

Double stranded RNAs (dsRNA) degrading nuclease is responsible for the rapid
degradation of dsRNA molecules, and thus accounts for variations in RNA interference …