Opinion statement Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune
disease of the central nervous system that primarily attacks the optic nerves and spinal cord …

Myasthenia gravis (MG) is a prototypical autoantibody mediated disease. The
autoantibodies in MG target structures within the neuromuscular junction (NMJ), thus …

Background: B cells may be involved in the pathophysiology of multiple sclerosis (MS).
Inebilizumab (formerly MEDI-551) binds to and depletes CD19+ B cells. Objectives: To …

B cells have important functions in the pathogenesis of autoimmune diseases, including
autoimmune rheumatic diseases. In addition to producing autoantibodies, B cells contribute …

Increasing recognition of the role of B cells in the adaptive immune response makes B cells
an important therapeutic target in autoimmunity. Numerous current and developmental …

Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of
the CNS that are primarily characterized by severe inflammation of the spinal cord and optic …

Exaggerated or inappropriate responses by B cells are an important feature in many types of
autoimmune neurological diseases. The recent success of B-cell depletion in the treatment …

Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the
neuromuscular junction. A small subset of patients (< 10%) with MG, have autoantibodies …

Autoimmune disorders of the CNS have complex pathogeneses that are not well
understood. In multiple sclerosis and neuromyelitis optica spectrum disorders, T cells …

For decades, B cells were ignored in multiple sclerosis (MS) pathogenesis, and the disease
was always regarded as a T cell‐mediated disorder. Recent evidence shows that there is an …