Hypertension and stroke are highly prevalent risk factors for cognitive impairment and
dementia. Alzheimer's disease (AD) and vascular dementia (VaD) are the most common …

The Amyloid precursor protein (APP) is a transmembrane glycoprotein from which amyloid-β
(Aβ) peptides are generated after proteolytic cleavage. Aβ peptides are the main constituent …

Objective: To assess seizure frequency in a large French cohort of autosomal dominant
early-onset Alzheimer disease (ADEOAD) and to determine possible correlations with …

We describe 56 novel autosomal dominant early-onset Alzheimer disease (ADEOAD)
families with PSEN1, PSEN2, and AβPP mutations or duplications, raising the total of …

Despite its key role in the molecular pathology of Alzheimer's disease (AD), the
physiological function of amyloid precursor protein (APP) is unknown. Increasing evidence …

We hypothesized that de novo variants (DNV) might participate in the genetic determinism of
sporadic early-onset Alzheimer disease (EOAD, onset before 65 years). We investigated 14 …

Background and Objective To report a triplication of the amyloid-β precursor protein (APP)
locus along with relative messenger RNA (mRNA) expression in a family with autosomal …

Among genetic susceptibility loci associated with late-onset Alzheimer disease (LOAD),
genetic polymorphisms identified in genes encoding lipid carriers led to the hypothesis that …

Background APP duplication is a rare genetic cause of Alzheimer disease and cerebral
amyloid angiopathy (CAA). We aimed to evaluate the phenotypes of APP duplications …

Research on Alzheimer disease (AD) genetics has provided critical advances to the
knowledge of AD pathophysiological mechanisms. The etiology of AD can be divided into …